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Opioid activity is because of each very low affinity binding from the father or mother compound and better affinity binding in the O-demethylated metabolite M1 to μ-opioid receptors. In animal designs, M1 is up to 6 periods additional powerful than tramadol in producing analgesia and 200 moments much more potent in μ-opioid binding.Tramadol inclu

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